# Isolation guitar solo > Mark Tremonti's guitar solo on Isolation by Alter Bridge (2010) starts at about 2:26. Played on a PRS Tremonti signature. A hard rock classic from the 2010s. Canonical URL: Alter Bridge, 2010. Solo by *Mark Tremonti*. A fast, riff-driven Tremonti burst packed with wide legato runs and pull-off flurries that never loses the song's momentum. Isolation by Alter Bridge is #2 in our ranking of the best Alter Bridge guitar solos. The solo is played by Mark Tremonti and the song was released in 2010. ## In our lists - [The Best Alter Bridge Guitar Solos](https://greatestsolos.com/list/alter-bridge-guitar-solos/) — #2 - [Top 20 Guitar Solos of 2010](https://greatestsolos.com/list/best-guitar-solos-2010/) — #4 ## Sources ### Who played the guitar solo on Isolation? Mark Tremonti played the solo on Alter Bridge's Isolation (2010). ### What guitar was used on the Isolation solo? A prs tremonti signature, according to widely reported accounts. --- GreatestSolos ranks the greatest guitar solos by consensus across published lists. Agent guide: [llms.txt](https://greatestsolos.com/llms.txt) · [Sitemap](https://greatestsolos.com/sitemap.xml) · [Dataset (CSV)](https://greatestsolos.com/data/greatest-guitar-solos.csv) · [How we rank](https://greatestsolos.com/method/)