# Trouble in Mind guitar solo > The guitar solo on Trouble in Mind by Sister Rosetta Tharpe (1949) starts at about 1:10. Watch from the solo, plus the story and gear. Canonical URL: Sister Rosetta Tharpe, 1949. Solo by *Sister Rosetta Tharpe*. A slow blues where her guitar sings with expressive, vocal-like phrasing, proving she could be as moving as she was fiery. Trouble in Mind by Sister Rosetta Tharpe is #8 in our ranking of the best Sister Rosetta Tharpe guitar solos. The solo is played by Sister Rosetta Tharpe and the song was released in 1949. ## In our lists - [The Best Sister Rosetta Tharpe Guitar Solos](https://greatestsolos.com/list/sister-rosetta-tharpe-guitar-solos/) — #8 - [The Best Guitar Solos of 1949](https://greatestsolos.com/list/best-guitar-solos-1949/) — #2 ## Sources ### Who played the guitar solo on Trouble in Mind? Sister Rosetta Tharpe played the solo on Sister Rosetta Tharpe's Trouble in Mind (1949). --- GreatestSolos ranks the greatest guitar solos by consensus across published lists. Agent guide: [llms.txt](https://greatestsolos.com/llms.txt) · [Sitemap](https://greatestsolos.com/sitemap.xml) · [Dataset (CSV)](https://greatestsolos.com/data/greatest-guitar-solos.csv) · [How we rank](https://greatestsolos.com/method/)