In My Darkest Hour
Megadeth, 1988, from So Far, So Good... So What!. Solo by Dave Mustaine.
Written in grief, it features Mustaine's most emotional soloing, moving from melancholic phrases to furious runs. It is regarded as one of his finest moments.
In My Darkest Hour by Megadeth is #8 in our ranking of the best Dave Mustaine guitar solos. The solo is played by Dave Mustaine and the song was released in 1988.
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Sources
Who played the guitar solo on In My Darkest Hour?
Dave Mustaine played the solo on Megadeth's In My Darkest Hour (1988).