Handshake Drugs
Wilco, 2005, from Kicking Television: Live in Chicago. Solo by Nels Cline.
Live, the song swells into a noisy guitar climax that immediately announced Cline's arrival in the band.
Handshake Drugs by Wilco is #5 in our ranking of the best Nels Cline guitar solos. The solo is played by Nels Cline and the song was released in 2005.
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Sources
Who played the guitar solo on Handshake Drugs?
Nels Cline played the solo on Wilco's Handshake Drugs (2005).
What guitar was used on the Handshake Drugs solo?
A fender jazzmaster, according to widely reported accounts.